Postdoctoral Fellow
Phone: +1 (530) 754 8285
Email: lrenault@ucdavis.edu

EXPERIENCE

• Since January 2006, Stahlberg Laboratory (UC Davis CA, USA)

        Post-Doctoral position in Cryo Electron Microscopy (single particle and electron crystallography) on membrane proteins

• September 2002 to December 2005, ”Ingénierie des Protéines” laboratory (CNRS-Marseille, France)

        Ph.D. training (supervisor, Dr. Pascale Marchot)
        Set up and fulfilled structure function relationship projects involving synaptic proteins and/or their structural homologues;
        Solved two crystal structures in collaboration with Dr. Yves Bourne (AFMB laboratory, Marseille, France);
        Contributed to the development of the ESTHER database (http://bioweb.ensam.inra.fr/ESTHER/general?what=index);
        Supervised trainees.

• January to June 2002, “Ingénierie des Protéines” laboratory (CNRS-Marseille, France)

        Six months D.E.A. (equivalent to master’s degree) research internship (supervisor, Dr Pascale Marchot).
        Purified, analyzed physico-chemically and functionally, and crystallized two macromolecules implicated in the architecture or the functioning of cholinergic synapses.

EDUCATION

• September 2002 to December 2005, Université de la Méditerrané

        ”Ingénierie des Protéines” laboratory (CNRS-Marseille, France)
        Ph.D. in Neurosciences supervised by Dr Pascale Marchot.
        Subject: Structural approach of the acetylcholinesterase inhibition by monoclonal antibodies [in French]. (PDF)
        Fellowships: “Association France-Alzheimer” (2003) and “Association Française contre les Myopathies” (2004 and 2005).

• September 2001 to June 2002, Université de la Méditerranée (Marseille, France)

        D.E.A. in Bioinformatics, Structural Biology and Genomic, equivalent to Master’s degree (4 month courses + 6 month internship in a research laboratory)
        Report for the research internship: Renault L. (2002) Biochemical and structural studies of macromolecules implicated in the architecture and the functioning of the cholinergic synapses [in French].

• September 1999 to Sept 2002,  Université de Rouen (France)

        European Magister in Integrative Biology, equivalent to Master’s degree (3 years validated by the D.E.A)
        Bibliographic report for the 2nd year: Vallet M.C. & Renault L. (2001) Multistationarity as a possible model for epigenesis [in English].

PUBLICATIONS

• Evans J.E., Renault L., and Stahlberg H. (2008) Structure determination using electron crystallography. In: 3D-Electron Microscopy in Life Sciences (a Textbook on DVD). Ed. A. Verkleij, E.V. Orlova, and A. Leis. First edition. 3DEM NETWORK of EXCELLENCE (European Union). in press
  

• Zeng X., Gipson B., Zhang Z.Y., Renault L., and Stahlberg H. (2007) Automatic lattice determination for two-dimensional crystal images. Journal of Structural Biology. 160(3), 353-361. Medline
  

• Renault L. and Stahlberg H. (2007) Three-dimensional electron microscopy of macromolecular assemblies (J. Frank), Book Review. Scanning. 29, 37. Scanning
  

• Renault L., Chou H.T., Chiu P.L., Hill R.M., Zeng X., Gipson B., Zhang Z.Y., Cheng A., Unger V., and Stahlberg H. (2006) Milestones in electron crystallography. J. Comp.-Aided Molec. Design. 20, 519-527. Medline

• Renault L., Nègre V., Hotelier T., Cousin X., Marchot P., & Chatonnet A. (2005) New friendly tools for users of ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins. Chem. Biol. Interact. 157-158, 339-343. Medline

• Bourne Y., Hasper A.A., Chahinian H., Renault L., Juin M.A., de Graaff L.H., & Marchot P. (2005) A. niger protein « EstA », perhaps a new electrotactin, defines a new class of fungal esterases within the alpha/beta hydrolase fold superfamily.  Chem. Biol. Interact. 157-158, 395-396. Medline

• Renault L., Essono S., Boquet D., Juin M., Grassi J., Bourne Y., & Marchot P. (2005) Structural insights into AChE inhibition by monoclonal antibodies. Chem. Biol. Interact. 157-158, 397-400. Medline

• Hotelier T., Renault L., Negre V., Marchot P., & Chatonnet A. (2004) ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins. Nucleic Acids Research 32, D 145-147. Medline
  

COMMUNICATIONS

• Renault L., Chou HT., Chiu PL., Zeng X., Gipson B., and Stahlberg H. (2007) Structural Studies of Membrane Proteins. Electron Crystallography at UC Davis. Poster to the Workshop on Advanced Topics in EM Structure Determination. Scripps San Diego, USA. (TIF)
  

• Renault L., Gruswitz F., Stroud R.M., and Stahlberg H. (2006) Regulation of the Ammonium Transporter: Electron Crystallography Study of the AmtB-GlnK Complex. Poster to the 2006 International Conference on Structural Genomics, Beijing, China. Young Scientist ISGO Travel Award. (TIF)

• Renault L., Essono S., Boquet D., Juin M., Grassi J., Bourne Y ., & Marchot P. (2005) Structural and theoretical insights into inhibition of acetylcholinesterase by monoclonal antibodies. Poster to the International Congress of Myology, Nantes, France. AFM Fellowship. (PDF)

• Renault L., Negre V., Hotelier T., Marchot P., & Chatonnet A. (2004) ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins. Oral and poster communication during the VIIIth International Meeting on Cholinesterases, Perugia, Italy. (Poster & Talk)

• Renault L., Essono S., Boquet D., Juin M., Grassi J., Bourne Y ., & Marchot P. (2004) Structural insights into AChE inhibition by monoclonal antibodies. Poster to the VIIIth International Meeting on Cholinesterases, Perugia, Italy. (PDF)
  

• Bourne Y., Hasper A.A., Chahinian H., Renault L., Juin M.A., de Graaff L.H., & Marchot P. (2004) A. niger protein « EstA », perhaps a new electrotactin, defines a new class of fungal esterases within the alpha/beta hydrolase fold superfamily. Poster to the VIIIth International Meeting on Cholinesterases, Perugia, Italy. (PDF)
  

• Renault L. (2003) Structural and functional study of acetylcholinesterase. Oral communication during the 5th Journées Scientifiques de l’IFR Jean Roche, Marseille, France.

• Renault L., Juin M.A., Bourne Y., Grassi J., & Marchot P. (2002) Acetylcholinesterase inhibition by a monoclonal amntibody sharing properties with fasciculin. Poster to the 10th Rencontres en Toxinologie; Toxines et Recherches Biomédicales. Société Française pour l’Etude des Toxines (SFET), Paris, France.